The package includes: - 30+ medical tests - doctor`s consultations - Accommodation (at clinic or 3* hotel) - Translation service (English, Chinese, Arabic, Russian, Ukrainian) - Transfer from/to airport - 24/7 support - Medical follow-up for 1 year *Stem cell material up to 60 million cells, (dosage and type of stem cell material are chosen by our doctors for each patient individually). **The list of examinations can be modified or enlarged in accordance with doctor’s recommendations. Each patient is provided with the Certificate of analysis of stem cell material confirming its quality. STEM CELL THERAPY IN GYNECOLOGY The schedule of the patient's stay (2 visits are necessary): - During the first visit to Vitality which lasts for 3 days we will make all the necessary tests; provide consultations with the therapist and gynecologist and if everything is fine, we will carry out the patients' biomaterial sampling procedure. Then the patient leaves us for 4-6 weeks while we’re cultivating patients' Stem Cells. In 4-6 weeks (when the Stem Cells are ready) we will invite the patient to undergo the procedure of cellular material administration. - During the second visit which lasts for 3 days, we'll provide laboratory diagnostics (basic biochemical and general clinical indicators); doctors' consultation on the results; Stem Cells administration. *The city tour is not included but can be organized additionally. Possible methods of cellular material administration: - In endometrium - Other methods of administration Indications to stem cell treatment: - Thin and non-receptive endometrium Сontraindications to treatment: - Malignant neoplasms - Critical disorders of blood coagulation system (platelet count ≤50×109) - Severe heart failure - Severe pulmonary failure (SpO2 <90%) - Kidney failure of IV-V degree - Infectious diseases in the acute phase (hepatitis C, hepatitis B, etc.) - Unstable hemodynamics, requiring correction with sympathomimetics - Terminal stage of incurable diseases - Acute stage of injuries or stroke - Pregnancy, pregnancy planning in the near future, breast feeding - Purulent joint diseases Therapeutic effects: The therapeutic effect of stem cells is achieved due to their ability to differentiate and transdifferentiate into tissue-specific cells, to fuse with the resident cells, to secrete a wide array of paracrine factors in order to stimulate the survival and functional recovery of the resident cells or to regulate the local microenvironment or immune response. Using MSC, we can achieve positive effects in those clinical cases, which were non- prospective in view of traditional options of therapy. The positive effects might be expected: Cell therapy trials for the treatment of endometrial pathologies, have reported promising findings, with demonstrable safety and early proof of efficacy, temporary amelioration of the intrauterine environment, and an increase in endometrial thickness, receptivity and as a result, increase in a chance for pregnancy. After the first injection, the endometrium grows by 6.5 mm. An increase in endometrial thickness may be measured by ultrasound diagnostic. Positive effects were reported in 76 % of cases during 6-9 months after stem cell therapy. What does the procedure look like? Stem cell treatment procedure is non-surgical, is practically painless, and is well-tolerated by patients. Possible short-term side effects immediately after cell transplantation are redness at the injection site and a slight increase in body temperature. These effects usually subside in 1 to 2 hours. The method of administration of cellular material is chosen by the doctor individually for each case. When will I see the results? Patient response to treatment is dependent on a large variety of biological factors, however is also subject to the behavior and lifestyle of the patient. We advise patients that stem cell therapy normally produces measurable results within 3-6-9 months following treatment. However, we have had many patients record improvements to their quality of life and a lessening of their symptoms within the first few weeks following treatment. Every patient is unique and will respond to treatment differently so it is impossible to guarantee any specific result for an individual, as every person’s body is different and will respond in different ways. Is it safe? Stem cell therapy using Mesenchymal Stem Cells is absolutely safe. There are no side effects associated with stem cell therapy. In very rare cases: a slight increase in temperature after the procedure is possible; slight redness at the injection site, - all these effects pass within a few hours. How do you operate during COVID-19? During COVID-19 we’re working on the same schedule following strict sanitation rules. In accordance with the Resolution of the Cabinet of Ministers of Ukraine dated July 22, 2020 No. 641 (taking into account the changes dated September 28, 2020), self-isolation is not subject for persons who test negative for COVID-19 by the polymerase chain reaction method, which is carried out no more than 48 hours before crossing the border. Please kindly note that it is possible to take the PCR test on arrival at the airport. ADONIS point of biomaterial sampling is located on the 2nd floor of Terminal D of Boryspil Airport (domestic flights departure area). You can find this item by the information signs set in Terminal D. Obligatory international insurance from COVID-19 - in Ukrainian insurance company. It can be short-term insurance (for example 1-3 months insurance or even several weeks), just to be active during the visit to Ukraine for the procedures. They check it in the airport. The patients can buy it online here https://visitukraine.today/ Are there any additional payments? All treatment packages include translation services in English, Chinese, Arabic, Russian Ukrainian. All other languages should be arranged and paid additionally. Accommodation included in package offers staying in clinic or at 3* hotel. Other accommodation options should be arranged and paid additionally. Treatment packages include transfer from/to the airport, all additional transfers are paid additionally.