The package includes: - 30+ medical tests - doctor`s consultations - Accommodation (at clinic or 3* hotel) - Translation service (English, Chinese, Arabic, Russian, Ukrainian) - Transfer from/to airport - 24/7 support - Medical follow-up for 1 year *Stem cell material up to 30 million cells; umbilical cord, menstrual blood, or adipose-derived stem cells may be used (dosage and type of stem cell material are chosen by our doctors for each patient individually). **The list of examinations can be modified or enlarged in accordance with doctor’s recommendations. Possible methods of cellular material administration: - intravenously - intraovarian Each patient is provided with the Certificate of Analysis of stem cell material confirming its quality. *In case of using your own stem cell material, 2 visits are needed. Package price rises by 25% The schedule of the patient's stay : Day 1 - arrival; Day 2- passing medical tests; Day 3- consultation with a specialized doctor, analysis of test results; Day 4 - consultation with therapist and stem cells injections; Day 5 - free day at the clinic, patient observation, departure; *The city tour is not included but can be organized additionally. Indications to stem cell treatment: - premature ovarian failure - amenorrhea - hypergonadotropism - hypoestrogenism - early menopause - prolongation of ovarian reserve - polycystic ovary syndrome Сontraindications to treatment: - Malignant neoplasms - Critical disorders of blood coagulation system (platelet count ≤50×109) - Severe heart failure - Severe pulmonary failure (SpO2 <90%) - Kidney failure of IV-V degree - Infectious diseases in the acute phase (hepatitis C, hepatitis B, etc.) - Unstable hemodynamics, requiring correction with sympathomimetics - Terminal stage of incurable diseases - Acute stage of injuries or stroke - Pregnancy, pregnancy planning in the near future, breastfeeding - Purulent joint diseases Therapeutic effects: Mesenchymal stem cell treatment improves hormone production, ovarian size, endometrial thickness, and endometrial blood flow. Stem cell treatment restores ovarian function and leads to the production of immature oocytes. In women, ultrasounds demonstrated that mesenchymal stem cell treatment improved both ovarian size and endometrial thickness of patients with premature ovarian failure. Moreover, blood flow analysis demonstrated a richer signal in the endometrium. In a recent study stem cell treatment of premature ovarian failure resumed menstruations and allowed a woman to get pregnant and to give birth to a full-term healthy baby. Menstruations restarted 3 months after stem cell therapy in 20% of treated women after the first stem cell administration, which regained ovarian reserve and the secretory function of a previously atrophic endometrium. Monitoring the worlds most reliable resources - PubMed, Cochrane, Embase, Scopus, and ProQuest shows 648 published studies on stem cell-based therapy for the treatment of various types of ovarian insufficiency and disorders, shows that stem cells could accelerate ovarian tissues rejuvenation, regulate systemic sex-related hormone levels and eventually increase fertility rate. The evidence suggests that stem cell-based therapies could be considered as an alternative modality to deal with women undergoing POI. What does the procedure look like? Stem cell treatment procedure is non-surgical, is practically painless and well-tolerated by patients. Possible short-term side effects immediately after cell transplantation are redness at the injection site and a slight increase in body temperature. These effects usually subside in 1 to 2 hours. The method of administration of cellular material is chosen by the doctor individually for each case. When will I see the results? Patient response to treatment is dependent on a large variety of biological factors, however is also subject to the behavior and lifestyle of the patient. We advise patients that stem cell therapy normally produces measurable results within 3-6-9 months following treatment. However, we have had many patients record improvements to their quality of life and a lessening of their symptoms within the first few weeks following treatment. Every patient is unique and will respond to treatment differently so it is impossible to guarantee any specific result for an individual, as every person’s body is different and will respond in different ways. Is it safe? Stem cell therapy using Mesenchymal Stem Cells is absolutely safe. There are no side effects associated with stem cell therapy. In very rare cases: a slight increase in temperature after the procedure is possible; slight redness at the injection site, - all these effects pass within a few hours. How do you operate during COVID-19? During COVID-19 we’re working on the same schedule following strict sanitation rules. In accordance with the Resolution of the Cabinet of Ministers of Ukraine dated July 22, 2020 No. 641 (taking into account the changes dated September 28, 2020), self-isolation is not subject for persons who test negative for COVID-19 by the polymerase chain reaction method, which is carried out no more than 48 hours before crossing the border. Please kindly note that it is possible to take the PCR test on arrival at the airport. ADONIS point of biomaterial sampling is located on the 2nd floor of Terminal D of Boryspil Airport (domestic flights departure area). You can find this item by the information signs set in Terminal D. Obligatory international insurance from COVID-19 - in Ukrainian insurance company. It can be short-term insurance (for example 1-3 months insurance or even several weeks), just to be active during the visit to Ukraine for the procedures. They check it in the airport. The patients can buy it online here https://visitukraine.today/ Are there any additional payments? All treatment packages include translation services in English, Chinese, Arabic, Russian, Ukrainian. All other languages should be arranged and paid additionally. Accommodation included in package offers staying in clinic or at 3* hotel. Other accommodation options should be arranged and paid additionally. Treatment packages include transfer from/to the airport, all additional transfers are paid additionally.